22.40 (routine)

$E2$ (aldehyde): moderate deactivator. - (ester acyloxy): moderate activator. - (hydroxyl): strong activator. - (trifluoromethyl): strong deactivator. - . > - C3 (CH₂): 2 H + 2 C = -2 + 0 = 1,2 vs 1,4 1.